CGRP Alpha (8-37), Human

Human α-CGRP(8-37) is a truncated calcitonin gene-related peptide that functions as a competitive CGRP-receptor antagonist. It is widely used to dissect CGRP-dependent vasodilation, nociception and GPCR signaling.

• CGRP receptor antagonism
• vascular signaling
• nociception and migraine research
• GPCR pharmacology

The peptide lacks the N-terminal seven residues of α-CGRP and is C-terminally amidated. This truncation is central to its antagonist activity.

1. Selected peer-reviewed publication