| GNYTCEVTELSREGKTVIELK, a powerful research-grade tool designed to accelerate discoveries in immunotherapy, cancer biology, and molecular signaling. Derived from the CD47 protein—a critical regulator of immune evasion and cellular homeostasis—this 21-amino-acid peptide is a cornerstone for researchers exploring the intricate interplay between tumor cells and the immune system. Backed by cutting-edge studies, such as those in Molecular Therapy (DOI: S1525-0016(25)00192-3), this peptide offers unmatched specificity and versatility for advancing therapeutic and biological research.
Applications in Research
The GNYTCEVTELSREGKTVIELK peptide, a segment of the CD47 extracellular domain, is meticulously engineered for a broad spectrum of research applications:
- Cancer Immunotherapy: This peptide is instrumental in studying CD47’s role as a “don’t eat me” signal, which tumors exploit to evade phagocytosis by macrophages. It’s ideal for developing anti-CD47 therapies aimed at enhancing immune-mediated tumor clearance.
- Immune Checkpoint Modulation: Investigate how this sequence interacts with signal-regulatory protein alpha (SIRP_) on immune cells, providing insights into blocking CD47-SIRP_ signaling to boost anti-tumor immunity.
- Tumor Microenvironment Studies: Use this peptide to probe the molecular dynamics of cancer cell survival and immune suppression within the tumor microenvironment.
- Drug Development: A key asset for designing peptide-based inhibitors or biologics targeting CD47, supporting precision oncology and novel therapeutic strategies.
- Cell Adhesion and Migration Research: Explore CD47’s influence on integrin-mediated cell adhesion and migration, critical for understanding metastasis and tissue repair.
Functions and Mechanisms
The GNYTCEVTELSREGKTVIELK peptide embodies the functional essence of CD47, offering researchers a window into its biological mechanisms:
- Phagocytosis Regulation: This sequence is part of the CD47 immunoglobulin-like domain that binds SIRP_, inhibiting phagocytic activity of macrophages and dendritic cells—a mechanism heavily exploited by cancer cells.
- Immune Evasion Inhibition: By mimicking this region, the peptide can be used to disrupt CD47-SIRP_ interactions, promoting immune recognition and destruction of pathological cells.
- High Binding Affinity: The specific arrangement of amino acids—featuring a mix of polar (e.g., Thr, Ser) and charged (e.g., Glu, Lys) residues—ensures strong and selective binding to target proteins, enhancing experimental precision.
- Structural Integrity: Its stable conformation under physiological conditions makes it a reliable candidate for in vitro and in vivo studies.
Biological Importance
The GNYTCEVTELSREGKTVIELK peptide is a critical fragment of CD47, a transmembrane protein overexpressed in numerous cancers, including leukemia, lymphoma, and solid tumors like breast and ovarian cancer. Its biological significance includes:
- Cancer Progression: CD47’s upregulation on tumor cells correlates with poor prognosis, making this peptide a vital tool for dissecting its role in immune escape and tumor survival.
- Therapeutic Potential: Research, such as that published in Molecular Therapy, highlights CD47-targeted approaches—using peptides like GNYTCEVTELSREGKTVIELK—to sensitize tumors to immune attack, paving the way for combination therapies with checkpoint inhibitors (e.g., anti-PD-1).
- Inflammation and Homeostasis: Beyond oncology, CD47 regulates macrophage activity in inflammatory diseases and red blood cell clearance, making this peptide relevant for studies in autoimmunity and anemia.
- Molecular Insights: The sequence’s involvement in signal transduction pathways offers a deeper understanding of cellular communication, bridging immunology and molecular biology.
Why Choose Our CD47 Peptide (GNYTCEVTELSREGKTVIELK)?
- Exceptional Purity: Synthesized at >98% purity using advanced HPLC and mass spectrometry validation for consistent, high-quality results.
- Customizable Options: Available in lyophilized form or solubilized to your specifications, with quantities tailored to your research scale.
- Research-Validated: Aligned with findings from leading journals like Molecular Therapy, ensuring relevance to cutting-edge science.
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