Biotinylated EGFR Tyr992 Phosphopeptide, Biotin-DADE-pY-LIPQQG

Biotin-DADE-pY-LIPQQG is a biotinylated phosphotyrosine peptide derived from the Tyr992 autophosphorylation region of the epidermal growth factor receptor (EGFR). The phosphorylated sequence is recognized by protein tyrosine phosphatases including PTP1B, while the N-terminal biotin enables affinity capture and immobilization. It is therefore useful for phosphatase assays, phosphotyrosine-binding studies, and EGFR phosphosite-related method development.

• protein tyrosine phosphatase assays
• PTP1B substrate studies
• streptavidin-based phosphopeptide capture
• EGFR Tyr992 phosphosite research

This is a pre-phosphorylated peptide and is most appropriate as a phosphatase substrate or phosphopeptide reagent rather than as an EGFR kinase substrate. The biotin tag can be used for capture but may alter solution-phase kinetics.

1. Protein-tyrosine phosphatase 1B substrate recognition and EGFR phosphopeptide studies