[Ala5, Beta-Ala8]-Neurokinin A (4-10)

Neurokinin A: HKTDSFVGLM

Neurokinin A (4-10): DSFVGLM

Neurokinin B: DMHDFFVGLM

Biotin-Neurokinin A: Biotin-HKTDSFVGLM

Biotin-Neurokinin B: Biotin-DMHDFFVGLM

Substance P: RPKPQQFFGLM

Physalaemin: pGlu-ADPNKFYGLM

Kassinin: DVPKSDQFVGLM

Eledoisin: pGlu-PSKDAFIGLM

Eledoisin Related Peptide: KFIGLM

[Ala5, Beta-Ala8]-Neurokinin A (4-10) is a synthetic research peptide in the neurokinin / tachykinin peptide family. Neurokinin A and neurokinin B belong to the tachykinin peptide family. Tachykinins signal through NK1, NK2, and NK3 G-protein-coupled receptors, with neurokinin A preferentially associated with NK2 and neurokinin B with NK3 pharmacology. Synthetic fragments and analogs have been used to map receptor-selective residues and define the contribution of the conserved tachykinin C-terminal region.

• NK1/NK2/NK3 receptor binding assays
• tachykinin receptor signaling experiments
• agonist and antagonist profiling
• peptide structure-activity studies
• analytical method development

For fragments, substituted analogs, labeled peptides, stereochemical variants, or terminally modified forms, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. Selective agonists for substance P and neurokinin receptors
2. Structure-activity relationship study of tachykinin peptides for neurokinin-3 receptor