Recombinant-Human-Transmembrane-protease-serine-2-TMPRSS2-Protein Published September 28, 2020 at 620 × 534 in The pivotal role of TMPRSS2 in COVID19 The pivotal role of TMPRSS2 in COVID19 Transmembrane serine protease 2 (TMPRSS2) is a serine protease that in humans is encoded by the TMPRSS2 gene.