Catalog Number | LT8877 |
Product Name | TAT (47-57), TAMRA-Labeled |
Product Quantity | 1 mg |
Sequence | TAMRA-YGRKKRRQRRR |
Molecular Weight | 1972.3 |
Formula | C93H142ClN35O20 |
Purity | ≥95% |
Scientific Background | TAMRA-YGRKKRRQRRR is a fluorescently labeled form of the HIV-1 Tat(47-57) cell-penetrating peptide. The parent 11-residue sequence is a canonical arginine-rich CPP used for intracellular delivery and membrane-translocation studies. TAMRA provides a red-orange fluorophore that enables direct imaging and quantitative analysis of peptide distribution and uptake. |
Research Applications | - TAT peptide uptake studies
- confocal fluorescence microscopy
- cell-penetrating peptide mechanism research
- fluorescent delivery-assay development
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Experimental Notes | TAMRA-labeled TAT has been used directly in membrane-translocation studies. Labeling can alter membrane association and trafficking, so results should be interpreted for the labeled construct rather than extrapolated automatically to unlabeled TAT. |
Selected References | - Confocal Laser Scanning Microscopy and Model Membranes to Study Translocation Mechanisms of Membrane Active Peptides
- Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
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