Catalog Number | LT8881 |
Product Name | TAT (47-57) GGG-Cys(Npys) |
Product Quantity | 1 mg |
Sequence | YGRKKRRQRRRGGG-C(Npys)-NH2 |
Molecular Weight | 1987.3 |
Formula | C78H135N39O19S2 |
Purity | ≥95% |
Scientific Background | YGRKKRRQRRRGGG-C(Npys)-NH2 combines the HIV-1 Tat(47-57) cell-penetrating sequence with a Gly3 spacer and a C-terminal Npys-activated cysteine. The flexible Gly3 linker separates the Tat transduction sequence from the activated thiol handle, making the construct useful for site-directed conjugation of Tat to thiol-containing molecules or carrier systems. |
Research Applications | - TAT cargo conjugation
- thiol-disulfide coupling studies
- cell-penetrating peptide delivery systems
- spacer-assisted peptide conjugation
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Experimental Notes | The Gly3 spacer and C(Npys) modification are integral parts of this construct. It should not be treated as equivalent to Cys(Npys)-TAT with the activated cysteine placed at the N terminus. |
Selected References | - Cellular Uptake of Antisense Morpholino Oligomers Conjugated to Arginine-Rich Peptides
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