Shepherdin (79-87) Peptide

Shepherdin(79-87) is a survivin-derived sequence used to investigate the interaction between survivin and the molecular chaperone Hsp90. The peptide provides a defined reagent for mechanistic binding and competition studies of this protein-complex interface.

• Hsp90-survivin interaction studies
• Competition and binding assays
• Peptide-conjugate development
• Cancer-cell signaling research

Activity reported for shepherdin constructs can depend on sequence length, delivery motif, conjugation and cell permeability. Results from modified or cell-penetrating variants should not be assumed for this unconjugated nine-residue peptide.

1. Rational design of shepherdin as an Hsp90-survivin antagonist
2. Bombesin-shepherdin conjugate research