Product Name | Plasminogen Activator Inhibitor 1 (PAI-1) |
Product Quantity | 5mg |
Catalog Number | LT2060 |
Molecular Weight | 673.79 |
Formula | C27H47N9O9S |
Sequence | Ala-Arg-Met-Ala-Pro-Glu |
Product Description | PAI-1 is a 50 kDa glycoprotein that belongs to the serine proteinase inhibitor superfamily which is the primary inhibitor of tissue- and urokinase-type plasminogen activators.The function of PAI-1 is to decrease fibrinolysis, leading to fibrin accumulation that is associated with thrombotic disease. Recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. |
Scientific Background | Plasminogen Activator Inhibitor 1 (PAI-1) is a 6-residue synthetic peptide with the sequence Ala-Arg-Met-Ala-Pro-Glu. The sequence has a relatively high hydrophobic-residue fraction that can influence aqueous solubility and surface adsorption. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
