Catalog Number | LT8763 |
Product Name | PKC-delta (8-17) Inhibitory Peptide, SFNSYELGSL |
Product Quantity | 1 mg |
Sequence | SFNSYELGSL |
Molecular Weight | 1116.2 |
Formula | C50H73N11O18 |
Purity | ≥95% |
Scientific Background | SFNSYELGSL corresponds to residues 8-17 of the V1 regulatory region of protein kinase C delta (PKC-delta) and has been used as an isozyme-selective inhibitory peptide in studies of PKC-delta translocation and signaling. Research using PKC-delta-selective peptide inhibition has helped define roles for this isozyme in cardiac, vascular and neuronal stress responses. |
Research Applications | - PKC-delta signaling studies
- PKC isozyme translocation research
- cell-signaling inhibitor studies
- comparative PKC isozyme experiments
|
Experimental Notes | Isozyme-selective effects depend strongly on delivery and intracellular access. For cell-based experiments, the unconjugated peptide should not be assumed to have the same uptake as cell-penetrating conjugates. |
Selected References | - Opposing cardioprotective actions and parallel hypertrophic effects of deltaPKC and epsilonPKC
- Protein Kinase C delta Mediates Cerebral Reperfusion Injury In Vivo
|
