Catalog Number | LT8760 |
Product Name | PD-1 Binding Peptide Ar5Y_2, FNWDYSLEELREKAKYK |
Product Quantity | 1 mg |
Sequence | FNWDYSLEELREKAKYK |
Molecular Weight | 2219.6 |
Formula | C103H151N25O30 |
Purity | ≥95% |
Scientific Background | FNWDYSLEELREKAKYK (Ar5Y_2) is a de novo designed peptide ligand of human PD-1 developed from structural features of the PD-1/PD-L1 interface. The original study reported micromolar PD-1 binding and identified the WDY-centered region as part of the designed interface. The peptide is useful for biochemical studies of PD-1 peptide recognition and competitive PD-1/PD-L1 binding. |
Research Applications | - PD-1 binding assays
- PD-1/PD-L1 competition studies
- immune-checkpoint peptide research
- protein-peptide interaction studies
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Experimental Notes | Reported binding is in the micromolar range and is assay-format dependent. This reagent is intended for mechanistic research rather than as an assumption of cellular or therapeutic potency. |
Selected References | - Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor
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