Catalog Number | LT8768 |
Product Name | NF-kappaB Nuclear Translocation Inhibitor SN50 |
Product Quantity | 1 mg |
Sequence | AAVALLPAVLLALLAPVQRKRQKLMP |
CAS Number | 213546-53-3 |
Molecular Weight | 2781.7 |
Formula | C129H230N36O29S |
Purity | ≥95% |
Scientific Background | SN50 is a synthetic cell-permeable peptide constructed by linking a hydrophobic membrane-translocating sequence to a nuclear localization sequence derived from the NF-kappaB p50 region. The original study showed that SN50 inhibits nuclear translocation of NF-kappaB-containing complexes and has therefore been widely used as a mechanistic probe of stimulus-dependent NF-kappaB nuclear import. |
Research Applications | - NF-kappaB nuclear translocation studies
- cell-signaling inhibition experiments
- nuclear localization research
- inflammatory signaling assays
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Experimental Notes | SN50 can affect nuclear transport processes beyond a single NF-kappaB complex, so specificity should be evaluated with suitable control peptides and pathway readouts. |
Selected References | - Inhibition of Nuclear Translocation of Transcription Factor NF-kappaB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence
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