| Myelin oligodendrocyte glycoprotein (MOG) 35-55, MEVGWYRSPFSRVVHLYRNGK, a minor component of CNS myelin, is a member of the immunoglobulin superfamily. It is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. MOG 35-55 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. Cysteine containing MOG (35-55) peptide can induce polyclonal anti-MOG(35-55) antibody production in rabbits with high specificity. Immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. |
