Mouse GEP Protein (LTP10330)

Product Name
Mouse GEP Protein (LTP10330)
Catalog Number
LTP10330
Quantity
100ug
Price
$406 In stock
Background
Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency.Loss of both PGRN and TMEM106B results in an increased accumulation of lysosomal vacuoles in the axon initial segment of motor neurons and enhances the manifestation of FTLD phenotypes with a much earlier onset.
Description
Recombinant Mouse GEP Protein is expressed from Expi293 with His tag at the C-terminal. It contains Thr18-Leu589.
Target
GEP
Species
Mouse
Gene/Protein ID
P28798
Exact Sequence
Thr18-Leu589
Molecular Weight
The protein has a predicted MW of 62.7 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on the Tris-Bis PAGE result.
Activity
0
Tag
C-His
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

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Mouse GEP Protein (LTP10330)
  • 5 Units in Stock
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