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| Mouse AXL Protein (LTP10286) |
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| LTP10286 |
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| 100ug |
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$203 In stock |
| Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. |
| Recombinant Mouse AXL Protein is expressed from Expi293 with His tag at the C-terminal. It contains His20-Trp445. |
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| AXL |
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| Mouse |
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| NP_033491.2 |
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| His20-Trp445 |
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| The protein has a predicted MW of 47.8 kDa. Due to glycosylation, the protein migrates to 68-78 kDa based on the Tris-Bis PAGE result. |
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| The affinity constant of 15.62 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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