Product Name | Mechano Growth Factor (MGF), E-domain Native |
Product Quantity | 1.0 mg |
Catalog Number | LT12019 |
Molecular Weight | 2868.19 |
Formula | C121H199N41O40 |
Sequence | H - Tyr - Gln - Pro - Pro - Ser - Thr - Asn - Lys - Asn - Thr - Lys - Ser - Gln - D - Arg - D - Arg - Lys - Gly - Ser - Thr - Phe - Glu - Glu - His - Lys - NH2 |
Purity | 98.77% |
Product Description | Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The peptide has the arginine amino acids replaced by the more stable D-arginines and the arginine on 23 is replaced by an histidine. MGF can act on muscles independently from the rest of the molecule. |
Scientific Background | Mechano Growth Factor (MGF), E-domain Native is a synthetic research peptide in the mechano growth factor (MGF) E-domain peptide category. Mechano growth factor is an IGF-1 splice-variant product containing a distinct E-domain sequence. Synthetic E-domain peptides have been reported to influence myoblast or progenitor-cell behavior in several experimental systems; however, other studies found that a defined C-terminal MGF peptide had no apparent effect on myoblasts or primary muscle stem cells. The literature is therefore context-dependent, and activity should not be generalized across different MGF peptide sequences. |
Research Applications | - MGF E-domain peptide studies
- myoblast/progenitor-cell experiments
- IGF-1 splice-variant research
- sequence-dependent activity comparisons
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Experimental Notes | The exact supplied sequence and modification state should be used when interpreting published results. Activity reported for a parent peptide, labeled derivative, formulation, species variant, or related analog should not automatically be assigned to this construct. |
Selected References | - Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblasts
- Defined MGF C-terminal peptide showed no apparent effect on myoblasts or primary muscle stem cells
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