Product Name | MDFDDDIPF |
Product Quantity | 4mg |
Catalog Number | LT343125 |
Sequence | MDFDDDIPF, C-terminal tail of E. coli SSB |
Purity | >95% |
Functional Insight | Key facilitator of DNA replication, repair, and recombination |
Biological Role | Enables interactions with DNA metabolism proteins |
Product Description | The nonapeptide MDFDDDIPF represents the C-terminal tail (CTP) of the single-stranded DNA-binding protein (SSB) in Escherichia coli. This region is critically involved in mediating interactions with various DNA metabolic proteins. The final 6–9 residues of the SSB C-terminus—including MDFDDDIPF—are highly conserved and vital for its functional partnerships and recruitment dynamics. MDFDDDIPF fosters essential interactions with DNA replication, repair, and recombination proteins by engaging conserved recognition surfaces on SSB. These interactions are central to genome maintenance and are mediated by the acidic repeats and hydrophobic residues in the tail. |
Scientific Background | MDFDDDIPF is a 13-residue synthetic peptide with the sequence Met-Asp-Phe-Asp-Asp-Asp-Ile-Pro-Phe-Thr-Ala-Ile-Leu. The sequence contains multiple acidic residues (4 Asp and 0 Glu), contributing negative charge at neutral pH; contains a relatively high fraction of hydrophobic residues, which can influence solubility and nonspecific adsorption. No specific receptor, enzyme, pathway, disease association, or biological activity is assigned to this peptide without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties are provided to support reagent selection and experimental planning. They do not establish a biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
