The nonapeptide MDFDDDIPF represents the C-terminal tail (CTP) of the single-stranded DNA-binding protein (SSB) in Escherichia coli. This region is critically involved in mediating interactions with various DNA metabolic proteins.
The final 6–9 residues of the SSB C-terminus—including MDFDDDIPF—are highly conserved and vital for its functional partnerships and recruitment dynamics. MDFDDDIPF fosters essential interactions with DNA replication, repair, and recombination proteins by engaging conserved recognition surfaces on SSB. These interactions are central to genome maintenance and are mediated by the acidic repeats and hydrophobic residues in the tail.
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