Catalog Number | LT8912 |
Product Name | M13 Skeletal Muscle MLCK / Calmodulin-Binding Peptide |
Product Quantity | 1 mg |
Sequence | KRRWKKNFIAVSAANRFKKISSSGAL |
Molecular Weight | 2964.7 |
Formula | C134H223N43O33 |
Purity | ≥95% |
Scientific Background | M13 is a peptide derived from the calmodulin-binding domain of skeletal-muscle myosin light-chain kinase (MLCK). The sequence forms a high-affinity interaction with Ca2+/calmodulin and is widely used as a model ligand for studying calmodulin target recognition, calcium-dependent conformational changes and peptide-calmodulin binding thermodynamics. |
Research Applications | - calmodulin-binding studies
- Ca2+/calmodulin signaling research
- MLCK regulatory-domain studies
- protein-peptide interaction assays
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Experimental Notes | M13 is primarily a calmodulin-binding peptide rather than a phosphoacceptor substrate for MLCK. Experimental descriptions should distinguish its regulatory binding role from peptides used directly as MLCK phosphorylation substrates. |
Selected References | - Effects of Myosin Light Chain Kinase and Peptides on Ca2+ Exchange with the N- and C-terminal Ca2+ Binding Sites of Calmodulin
- Hydrophobic peptides affect binding of calmodulin and Ca2+ as explored by H/D amide exchange and mass spectrometry
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