Catalog Number | LT9003 |
Product Name | KALA Amphipathic Cell-Penetrating Peptide |
Product Quantity | 1 mg |
Sequence | WEAKLAKALAKALAKHLAKALAKALKACEA |
CAS Number | 187987-64-0 |
Molecular Weight | 3132.1 |
Formula | C144H248N40O35S |
Purity | ≥95% |
Scientific Background | KALA is a synthetic cationic amphipathic peptide designed to bind nucleic acids and interact with lipid bilayers. It adopts an alpha-helical conformation under physiological conditions and can disrupt membranes, properties that have made it useful in experimental DNA and oligonucleotide delivery systems. |
Research Applications | - DNA and oligonucleotide delivery
- cell-penetrating peptide studies
- membrane permeabilization research
- nonviral transfection research
|
Experimental Notes | KALA is membrane-active and can perturb lipid bilayers; delivery experiments should distinguish productive transfection from nonspecific membrane disruption or toxicity. Peptide-to-cargo ratio and buffer conditions are important. |
Selected References | - Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers
|
