(Arg)9, Cys C-term

Product Name
(Arg)9, Cys C-term
Product Quantity
1mg
Catalog Number
LT8113
Molecular Weight
1526.84
Formula
C57H115N37O11S
Sequence
(Arg)9, Cys C-term, RRRRRRRRRC
Purity
>95%
More Details
How to Make Your Peptide Cell Permeable?
Product Description
The peptide has nine Arginine residues and is modified with an activated cysteine residue C(Npys). The Npys is 3-Nitro-2-pyridinesulfenyl group-protected cysteine. The peptide is used as a carrier peptide in conjugation and cell-permeable studies. The C(Npys) group will react selectively with the free thiol group of any other proteins or antibodies containing a free cysteine. The coupling of sulfhydryls has been studied as an effective means to deliver/release therapeutics such as siRNA in the reducing environment within the cell. It was used for antibody-mediated delivery of siRNAs for anti-HIV therapy.
Scientific Background

(Arg)9, Cys C-term is a 10-residue synthetic peptide with the sequence Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Cys. The sequence contains 1 cysteine residue, providing potential thiol/disulfide chemistry when the thiol is available; contains 0 Lys and 9 Arg residues, contributing cationic character. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

Research Applications
  • thiol-selective conjugation or immobilization studies
  • LC-MS/HPLC analytical method development
  • sequence-specific assay controls
Experimental Notes

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.

  • 19 Units in Stock
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