{Myr}-RQIKIWFQNR RMKWKKGGEI KDDVIEECNK HGGVIHIYVD KNSAQGNVYV HHHHHH

{Myr}-RQIKIWFQNR RMKWKKGGEI KDDVIEECNK HGGVIHIYVD KNSAQGNVYV HHHHHH is a synthetic penetratin cell-penetrating peptide-containing construct. This product contains penetratin, RQIKIWFQNRRMKWKK, a 16-residue cell-penetrating sequence derived from the Antennapedia homeodomain. Biophysical studies show that its cationic residues contribute strongly to membrane interaction and cellular internalization.

• cellular uptake studies
• cargo-delivery experiments
• membrane-binding assays
• cell-penetrating peptide structure-function studies

The behavior of a motif embedded in a longer peptide can differ from the isolated tag or parent sequence. Flanking residues, linkers, phosphorylation, fluorophores, affinity handles, cyclization, and terminal modifications may alter accessibility, binding, uptake, or assay performance.

1. Membrane interaction and cellular internalization of penetratin
2. Benzophenone-based studies of penetratin membrane interactions