Histone H4 (1-25) K12Ac/K16Ac/K20Me3-GSGSK(Biotin)

Catalog Number
LT9088
Product NameHistone H4 (1-25) K12Ac/K16Ac/K20Me3-GSGSK(Biotin)
Product Quantity1 mg
SequenceSGRGKGGKGLG-K(Ac)-GGA-K(Ac)-RHR-K(Me3)-VLRDN-GSGSK(Biotin)
Molecular Weight3359.1
Purity≥95%
Scientific Background

This combinatorially modified H4 peptide contains acetylation at Lys12 and Lys16 together with trimethylation at Lys20. It provides a defined reagent for studying crosstalk between H4 acetylation and H4K20 methylation in chromatin-reader recognition.

Research Applications
  • histone PTM crosstalk
  • H4K20Me3 reader studies
  • acetyl/methyl combinatorial binding
  • streptavidin pull-down assays
Experimental Notes

The two acetyl marks, K20 trimethylation and GSGSK(Biotin) handle all define this exact product. It should not be substituted with the diacetylated H4K12/K16 peptide or a K20Me3-only construct.

Selected References
  1. Selected histone H4 study
  2. Selected histone H4 study
  • 1 Units in Stock
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$469.00

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