Histone H4 (1-23)-GGK(Biotin)-NH2

Histone H4(1-23)-GGK(Biotin)-NH2 is an unmodified H4 tail reference peptide carrying a C-terminal biotinylated lysine and terminal amide. The H4(1-23) region contains Arg3 and Lys20, two important histone methylation sites, making this construct a useful immobilizable control for modification-dependent binding studies.

• histone reader binding
• streptavidin pull-down assays
• H4 methylation controls
• epigenetic assay development

The GGK(Biotin)-NH2 extension is part of the exact product identity. This form is distinct from free-acid H4(1-23) biotin constructs and from H4(1-21) or H4(1-25) peptides.

1. Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor