Histone H4 (1-23) K20Me3-GGK(Biotin)-NH2

H4K20me3 is associated with compact chromatin and heterochromatin organization and represents a distinct endpoint of Lys20 methylation. This peptide provides a site-specific trimethyllysine ligand with a biotin capture handle.

• heterochromatin research
• H4K20 methylation-state profiling
• methyl-lysine reader binding
• epigenetic assay development

Trimethylation at Lys20 is chemically and functionally distinct from H4K20me1 and H4K20me2. The terminal amide and biotin extension are part of this exact product form.

1. Degrees make all the difference: The multifunctionality of histone H4 lysine 20 methylation