Catalog Number | LT9050 |
Product Name | Histone H4 (1-21) K16Ac-GGK(Biotin) |
Product Quantity | 1 mg |
Sequence | Ac-SGRGKGGKGLGKGGA-K(Ac)-RHRKV-GGK(Biotin) |
Molecular Weight | 2644.2 |
Purity | ≥95% |
| Scientific Background | H4K16ac is a prominent chromatin mark that can modulate higher-order chromatin structure and is recognized in combinatorial chromatin-reading mechanisms. This biotinylated H4(1-21) peptide provides a defined reagent for H4K16ac-sensitive binding assays. |
| Research Applications | - H4K16ac reader-protein studies
- chromatin compaction research
- ZMYND8-related binding assays
- epigenetic screening
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| Experimental Notes | This is the N-terminally acetylated, site-specifically K16-acetylated GGK(Biotin) form and is distinct from the tetra-acetylated H4 peptide. |
| Selected References | - Selective recognition of H3.1K36 dimethylation/H4K16 acetylation facilitates regulation by ZMYND8
- Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
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