Histone H4 (1-21) K12Ac-GGK(Biotin)

H4K12ac is a major acetylated histone H4 state involved in chromatin assembly and transcription-associated regulation. The site-specific biotinylated peptide is useful for studying acetylation-sensitive reader proteins and histone-binding complexes.

• H4K12ac reader studies
• histone chaperone research
• chromatin protein pull-downs
• epigenetic assay development

The N-terminal acetyl group, Lys12 acetylation and GGK(Biotin) extension are all retained from the current vendor specification.

1. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro