Histone H3 (26-46)

Histone H3(26-46) spans Lys27 and Lys36, two major regulatory sites whose methylation states are central to Polycomb repression and transcription-associated chromatin. The unmodified fragment provides a defined reference substrate for enzymes and readers acting on this region.

• H3K27/H3K36 enzyme assays
• chromatin reader studies
• histone modification controls
• epigenetic screening

This is the unmodified free-acid fragment. Use it as a matched control for site-specifically modified H3 peptides covering the same region.

1. Histone H3 lysine 36 methylation is associated with transcriptional elongation and recruits chromatin-regulatory proteins