| Product Name | Histone H3 (23-34) |
| Sequence | KAARKSAPATGG |
| Mechanism & Biological Significance | Histone H3(23-34) is a compact unmodified H3 fragment centered on Lys27. Because Lys27 can be acetylated or mono-, di- or trimethylated, the unmodified peptide is a matched reference for assays that compare modification-dependent recognition at this regulatory site. |
| Published Research Context | A peer-reviewed HMGN/chromatin study explicitly used the exact KAARKSAPATGG peptide from the commercial supplier alongside the exact H3K27ac counterpart. The peptide served as a defined competitor/control in experiments dissecting whether HMGN preference for acetylated nucleosomes could be explained by the isolated H3K27 region. A separate peptide-sensing study also used exact H3(23-34) as a sequence-defined histone control. |
| Drug Discovery & Assay Relevance | matched control for H3K27 modification assays |
| Research Applications | - matched control for H3K27 modification assays
- histone-reader and antibody binding controls
- chromatin-protein interaction studies
- peptide analytical/sensing controls
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| Experimental Considerations | This free-acid 12-mer is distinct from longer H3(21-44) constructs and from biotinylated or terminally amidated versions. Binding and enzyme behavior should not be transferred across peptide length or terminal chemistry. |
| Selected Scientific References | - Exact H3(23-34) and H3K27ac(23-34) used in chromatin-binding experiments
- Exact H3(23-34) used as a defined histone peptide in a sensing study
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