Histone H3 (23-34) K27Me3

H3K27me3 is the canonical Polycomb-associated repressive histone mark and is recognized by chromodomain-containing Polycomb proteins. This minimal H3(23-34) peptide provides a compact trimethyl-lysine ligand for biochemical binding and methylation-state studies.

• H3K27me3 reader binding
• Polycomb chromatin studies
• PRC2 pathway research
• epigenetic assay controls

H3K27me3 is biologically and chemically distinct from K27me1 and K27me2. Preserve the trimethylated lysine state when reproducing reader-domain or antibody-binding experiments.

1. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer