Histone H3 (21-44) K27Me1-GK(Biotin)

H3K27me1 is a monomethylated state of Lys27 within the histone H3 tail. K27 methylation is a central regulatory axis in Polycomb-associated chromatin, and the monomethyl state has biochemical and genomic properties distinct from H3K27me2 and H3K27me3.

• H3K27 methylation studies
• PRC2-related assays
• chromatin reader binding
• streptavidin pull-down experiments

This product is the free-acid GK(Biotin) form. It should be treated separately from K27Me2, K27Me3 and amidated biotinylated H3 constructs.

1. Quantitative Mass Spectrometry of Histones H3.2 and H3.3 in Suz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36