Catalog Number | LT9031 |
Product Name | Histone H3 (21-44) K27Me1/K36Me1-GK(Biotin) |
Product Quantity | 1 mg |
Sequence | ATKAAR-K(Me1)-SAPATGGV-K(Me1)-KPHRYRPG-GK(Biotin) |
Molecular Weight | 2945.6 |
Purity | ≥95% |
| Scientific Background | This doubly modified H3 tail carries monomethylation at both Lys27 and Lys36. Because K27 and K36 modifications can encode opposing or context-dependent chromatin states, a peptide bearing both marks is useful for studying modification crosstalk and reader/enzyme selectivity. |
| Research Applications | - histone modification crosstalk
- K27/K36 methylation studies
- reader-protein binding
- epigenetic enzyme profiling
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| Experimental Notes | Both methyl marks and the free-acid GK(Biotin) linker are part of the exact reagent identity. Do not substitute a single-site methylated peptide in comparative binding studies. |
| Selected References | - Quantitative Mass Spectrometry of Histones H3.2 and H3.3 in Suz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36
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