| Product Name | Histone H3 (1-8) |
| Product Quantity | 1 mg |
| Sequence | ARTKQTAR |
| Molecular Weight | 931.1 |
| Purity | ≥95% |
| Mechanism & Biological Significance | ARTKQTAR is the free-N/free-C eight-residue N-terminal fragment of histone H3. The peptide contains Lys4 and provides a compact H3-tail reagent for studying chemical or enzymatic modification of the H3 N terminus. |
| Published Research Context | The exact H2N-ARTKQTAR-COOH construct was used directly in a peer-reviewed study of temozolomide-mediated histone methylation. The investigators specified the same 1-8 sequence, free termini, molecular weight and greater-than-95% HPLC purity and characterized methylated reaction products by LC-MS/MS. |
| Research Applications | - histone H3 N-terminal modification studies
- LC-MS/MS reaction-product analysis
- histone methylation chemistry
- sequence-defined H3 controls
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| Experimental Considerations | Do not transfer data from H3K4-methylated, extended, biotinylated or carrier-conjugated H3 peptides to this exact free-acid construct without verification. |
| Selected Scientific References | - Histone Methylation by Temozolomide; A Classic DNA Methylating Anticancer Drug
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