Histone H3 (1-21) K4Me3-GGK(Biotin)-NH2

H3K4me3 is a hallmark modification enriched near active transcription start sites. This peptide combines trimethylated Lys4 with a C-terminal GGK-biotin capture handle, enabling biochemical analysis of PHD fingers and other reader domains that recognize H3K4 methylation states.

• H3K4me3 reader-domain binding
• PHD finger studies
• chromatin protein pull-downs
• epigenetic assay development

The terminally amidated biotin construct is chemically distinct from free-acid H3K4me3-GGK(Biotin). Preserve the exact terminal form when comparing binding measurements.

1. Global Mapping of H3K4me1 and H3K4me3 Reveals the Chromatin State-Based Cell Type-Specific Gene Regulation in Human Treg Cells