Catalog Number | LT9015 |
| Product Name | Histone H3 (1-21) K4Me3-GGK(Biotin)-NH2 |
| Product Quantity | 1 mg |
| Sequence | ART-K(Me3)-QTARKSTGGKAPRKQLA-GGK(Biotin)-NH2 |
| Molecular Weight | 2765.4 |
| Formula | |
| Purity | ≥95% |
| Scientific Background | H3K4me3 is a hallmark modification enriched near active transcription start sites. This peptide combines trimethylated Lys4 with a C-terminal GGK-biotin capture handle, enabling biochemical analysis of PHD fingers and other reader domains that recognize H3K4 methylation states. |
| Research Applications | - H3K4me3 reader-domain binding
- PHD finger studies
- chromatin protein pull-downs
- epigenetic assay development
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| Experimental Notes | The terminally amidated biotin construct is chemically distinct from free-acid H3K4me3-GGK(Biotin). Preserve the exact terminal form when comparing binding measurements. |
| Selected References | - Global Mapping of H3K4me1 and H3K4me3 Reveals the Chromatin State-Based Cell Type-Specific Gene Regulation in Human Treg Cells
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