gp91ds-tat NADPH Oxidase Inhibitory Peptide

gp91ds-tat is a cell-permeable peptide inhibitor designed to disrupt assembly of the NOX2/gp91phox NADPH oxidase complex. The construct combines an HIV Tat-derived cell-penetrating sequence with a gp91phox docking-sequence peptide. It has been widely used in vascular and neuronal studies to test the contribution of NOX2-dependent reactive oxygen species to signaling, vascular responses and oxidative stress.

• NOX2/NADPH oxidase inhibition studies
• reactive oxygen species research
• vascular signaling experiments
• cell-permeable peptide inhibitor studies

gp91ds-tat is a mechanistic inhibitor of NADPH oxidase assembly rather than a general antioxidant. Scrambled gp91-tat controls are useful for distinguishing sequence-dependent inhibition from Tat-mediated delivery effects.

1. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide
2. NADPH oxidase has a directional response to shear stress