[Gly22]-Beta-Amyloid (1-42), Arctic Mutation

The E22G Arctic mutation in the Aβ42 background provides a strongly aggregation-relevant familial variant. It has been used to study enhanced formation of toxic soluble amyloid assemblies.

• familial amyloid mutation studies
• Aβ aggregation and oligomerization
• Alzheimer disease research
• mutant versus wild-type comparisons

Mutation identity and Aβ C-terminal length are integral to this reagent. Compare with the sequence-matched wild-type Aβ40 or Aβ42 under identical preparation and aggregation conditions.

1. Selected mutation/amyloid study