Product Name | FAM-Cys-iRGD |
Product Quantity | 1mg |
Catalog Number | 8197 |
Molecular Weight | 1521.67 |
Formula | C65H84N16O21S3 |
Sequence | FAM-Cys-Ahx-CRGDKGPDC, Disulfide Bridge: 3-11, N-terminal: FAM, C-Terminal: Amidation |
Purity | >95% |
Product Description | 
Peptides containing an arginine-glycine-aspartic acid (RGD) motif (RGD peptides) are known to recognize and bind to the integrin receptors. A disulfide-based cyclic RGD peptide, c(CRGDKGPDC) (iRGD), which interacts with the integrin and neurophilin-1 receptors, was shown to facilitate deeper penetration of imaging agents and anticancer medicines compared with the original RGD peptide. |
Scientific Background | FAM-Cys-iRGD is a 9-residue synthetic peptide with the sequence Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys. FAM provides a fluorescent label for optical detection; an Ahx spacer separates the peptide from an attached label or affinity handle. The sequence contains 2 cysteine residues, providing potential thiol/disulfide chemistry when the thiol is available. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - fluorescence-based detection
- binding or localization assay development
- thiol-selective conjugation or immobilization studies
- LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
