Endothelin-1, Human

Endothelin-1 is a 21-residue disulfide-rich vasoactive peptide and one of the most potent endogenous vasoconstrictors. It signals through ETA and ETB receptors and is central to vascular tone, pulmonary hypertension, fibrosis and cardiovascular remodeling research.

• cardiovascular and vascular signaling
• GPCR/receptor pharmacology
• endothelial and angiogenesis research
• peptide-processing studies

Disulfide connectivity, C-terminal amidation and exact precursor boundaries are integral to biological activity. Preserve the specified molecular form when comparing receptor or enzyme assays.

1. Selected peer-reviewed publication