Catalog Number | LT9000 |
| Product Name | Endothelin-1, Human, HiLyte Fluor 488-Labeled |
| Product Quantity | 0.25 mg |
| Sequence | HiLyte™ Fluor 488-CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1-15 and 3-11) |
| Molecular Weight | 2848.4 |
| Purity | ≥95% |
| Scientific Background | HiLyte Fluor 488-endothelin-1 is a fluorescent form of the 21-residue vasoactive peptide endothelin-1. Native ET-1 contains two disulfide bridges and signals through endothelin GPCRs to regulate vascular tone and cardiovascular signaling. The green fluorophore enables ligand binding and localization studies. |
| Research Applications | - endothelin receptor binding
- vascular signaling studies
- fluorescent ligand tracking
- GPCR internalization research
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| Experimental Notes | Both native disulfide bridges are part of the active ET-1 fold and must be preserved. The fluorophore can change receptor affinity or trafficking, so use native ET-1 as a functional control. |
| Selected References | - Endothelin-1 and the cardiovascular system
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