EGFR Protein Tyrosine Kinase Substrate, ADEYLIPQQ

ADEYLIPQQ is a compact tyrosine-containing peptide used as a substrate for epidermal growth factor receptor (EGFR) protein tyrosine kinase. The central tyrosine serves as the phosphoacceptor, allowing the peptide to function as a defined reagent for EGFR kinase activity measurements, phosphorylation assays, and comparative inhibitor studies.

• EGFR kinase activity assays
• tyrosine phosphorylation studies
• EGFR inhibitor screening
• protein tyrosine kinase assay development

Short peptide substrates can also be phosphorylated by other protein tyrosine kinases. EGFR selectivity should therefore be established using purified enzyme or appropriate pathway controls.

1. Protein tyrosine kinase peptide substrate profiling