EAEDLQ-{D8-Val}-GQ-{D8-Val}-ELGGGPGAGSLQPLALEGSLQ is a synthetic peptide, characterized by its specific sequence and incorporation of deuterated valine residues ({D8-Val}). This peptide is of interest in various biological research applications, particularly in studies focused on protein structure, protein-protein interactions, and biomolecular dynamics.
Applications in Biological Research
The incorporation of deuterated amino acids, such as {D8-Val}, into peptides allows researchers to use techniques like NMR spectroscopy and mass spectrometry to investigate the structural and functional properties of proteins at a more detailed level. This specific labeling provides enhanced sensitivity and resolution, making it easier to study complex biomolecular interactions and conformational changes that occur during protein folding, binding, and other biological processes.
Function and Mechanisms of Action
This peptide sequence is particularly useful in the study of protein dynamics, as the deuteration allows for clearer differentiation of overlapping signals in NMR spectra, which is crucial for understanding the detailed mechanisms of protein interactions and their implications in various cellular processes. By analyzing how this peptide interacts with other molecules or within its structure, researchers can gain insights into the functional roles of similar sequences in larger protein complexes.
Significance in Drug-Related Research
In drug discovery and development, understanding the detailed structural dynamics of target proteins is essential. Peptides like EAEDLQ-{D8-Val}-GQ-{D8-Val}-ELGGGPGAGSLQPLALEGSLQ serve as model systems or as parts of larger protein domains that can be studied to design drugs that modulate protein function. The ability to track changes in conformation and interaction dynamics with high precision makes this peptide a valuable tool in the development of new therapeutic strategies.
Molecular and Storage Information
The peptide’s chemical formula is indicative of its complex structure, which includes specific labeled residues for advanced analytical studies. Proper storage conditions are necessary to maintain its stability and ensure the accuracy of experimental results when used in sensitive techniques like NMR or mass spectrometry.
EAEDLQ-{D8-Val}-GQ-{D8-Val}-ELGGGPGAGSLQPLALEGSLQ is thus an essential component in cutting-edge research focused on protein chemistry, molecular biology, and drug development, providing crucial insights into the molecular mechanisms that underlie health and disease.
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