C-Type Natriuretic Peptide (32-53), Human/Porcine

C-type natriuretic peptide (CNP-22) is a 22-residue cyclic peptide with a disulfide bridge between Cys6 and Cys22. The sequence GLSKGCFGLKLDRIGSMSGLGC is the mature CNP-22 sequence and is highly conserved across mammalian species. CNP preferentially activates natriuretic peptide receptor-B/guanylyl cyclase-B (NPR-B/GC-B), increasing intracellular cGMP, and is widely studied in vascular, skeletal-growth and natriuretic-peptide signaling research.

• NPR-B/GC-B receptor signaling studies
• cGMP pathway research
• cardiovascular peptide research
• CNP structure-function studies

The Cys6-Cys22 disulfide bridge is integral to the mature cyclic peptide and must be preserved in the product definition. Biological response depends on receptor expression and assay conditions.

1. C-Type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain
2. C53: A Novel Particulate Guanylyl Cyclase B Receptor Activator