Catalog Number | LT8865 |
Product Name | CREBtide Phosphorylated Peptide, C-terminal Lys |
Product Quantity | 1 mg |
Sequence | KRREILSRRPS-pY-RK |
Molecular Weight | 1925.2 |
Formula | C79H142N31O23P |
Purity | ≥95% |
Scientific Background | KRREILSRRPS-pY-RK is a phosphorylated CREBtide-derived peptide containing a pre-installed phosphotyrosine and an added C-terminal lysine. The underlying CREBtide sequence was developed from the cAMP response element-binding protein phosphorylation region and is widely used as a kinase substrate framework. This phosphorylated derivative is best positioned as a defined phosphopeptide reagent for phosphorylation-state, analytical and phosphatase studies. |
Research Applications | - phosphopeptide analytical controls
- phosphorylation-state studies
- phosphatase assay development
- CREB-derived peptide research
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Experimental Notes | The supplied peptide is already phosphorylated and should not be described as the unmodified CREBtide PKA substrate. The pTyr-containing sequence also differs from canonical serine-phosphorylated CREB biology, so use it as a chemically defined research reagent. |
Selected References | - Analysis of Phosphorylated Peptides by Ion Mobility-Mass Spectrometry
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