Cathepsin B Substrate, Z-RR-AMC

Z-RR-AMC is a fluorogenic dibasic substrate commonly used to measure cathepsin B and related cysteine protease activity. Cleavage liberates AMC for fluorescence detection.

• caspase and apoptosis research
• protease activity assays
• inflammasome or cytotoxicity studies
• enzyme inhibitor profiling

Reporter group and terminal warhead are integral to reagent identity. AMC and pNA substrates require different detection modes, while aldehyde derivatives are inhibitors rather than turnover substrates.

1. Selected peer-reviewed publication