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This peptide is derived from the Nerve Growth Factor (NGF) precursor, specifically from the proNGF protein. ProNGF is cleaved into smaller peptides, including LIP1 (29 amino acids) and LIP2 (38 amino acids), which have been shown to possess biological activity. These peptides are present in the rat intestine and have been demonstrated to induce rapid phosphorylation of the Trk receptor in cell lines. They exert an anti-proliferative effect on the mitogenic activity of estrogen and IGF in MCF-7 cells and protect against in vivo induction of excitotoxic lesions by the glutamatergic analogue ibotenate injected into the developing mouse brain. Additionally, they bind to murine microglial cells and induce phosphorylation of Akt, suggesting a role in cell survival.
Given its origin from proNGF, YFLFRPRN may have applications in the following areas:
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Neuroprotection: Due to its ability to protect against excitotoxic lesions, this peptide could be explored for therapeutic strategies in neurodegenerative diseases.
- Cell Survival Studies: Its interaction with microglial cells and induction of Akt phosphorylation suggests potential in studying cell survival pathways.
- Cancer Research: The anti-proliferative effects on MCF-7 cells make it a candidate for investigating growth inhibition mechanisms in cancer cells.
- Diagnostic Imaging: Conjugating with imaging agents to visualize tumors and other pathological conditions where integrins are overexpressed.
- Signal Transduction: Understanding its role in receptor phosphorylation can provide insights into signaling pathways mediated by NGF and its precursors.
For researchers interested in the biological activities of proNGF-derived peptides, YFLFRPRN offers a valuable tool for exploring neuroprotective mechanisms and cell survival pathways.
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