Beta-Amyloid (12-28), human

Product Name
Beta-Amyloid (12-28), human
Product Quantity
1 mg, 97.13% Purity
Product Description
Beta amyloid 1-42 is known as a biomarker of Alzheimer's disease. Amyloid is detectable in cerebrospinal fluid (CSF). It is a 42-amino acid fragment of amyloid precursor protein. The peptide is well suited for use as a standard in the quantitation of Alzheimer's. Beta amyloid (12–28) residues are the binding site for apolipoprotein E (apoE) on Beta amyloid. This sequence encompasses a hydrophobic domain (residues 14–21) and a beta-turn (residues 22–28) which place two hydrophobic domains of Beta amyloid 14 to 21 and 29 to 40/42 opposite each other, allowing for the assembly of Beta amyloid peptides into fibrils. The secondary structure of Beta amyloid (12- 28), a neutral peptide, is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of Beta amyloid is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of Aß pathology in Alzheimer’s disease (AD). Beta amyloid (11-28) and five other fragments enhanced aggregation of full length Beta amyloid (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length Beta amyloid. Injection of the amyloid beta-protein fragment VHHQKLVFFAEDVGSNK into different limbic system structures in mice impaired retention with remarkably similar efficacy and in a dose-dependent manner. Beta amyloid (12-28) and other Beta amyloid fragments may exert dysregulatory cognitive effects by incoordination of K? channel function in neurons, glia and endothelial cells.
Catalog Number
L33
Molecular Weight
1955.2
Formula
C89H135N25O25
Sequence
H - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - OH, VHHQKLVFFAEDVGSNK,
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