Bac2A / Bactenecin 2A Peptide

Bac2A is a linear cationic derivative of bovine bactenecin in which the two cysteines of the native cyclic peptide are replaced by alanines. This substitution removes the intramolecular disulfide and produces a short linear antimicrobial peptide that has been widely used for sequence-optimization and structure-activity studies. Published optimization work with Bac2A derivatives helped define the contribution of charge, hydrophobicity and residue position to antibacterial activity.

• antimicrobial peptide structure-activity studies
• bactenecin analog research
• bacterial growth-inhibition assays
• cationic peptide optimization

Bac2A is linear and should not be treated as structurally equivalent to disulfide-cyclized native bactenecin. Antimicrobial activity depends strongly on assay medium and ionic conditions.

1. Sequence Requirements and an Optimization Strategy for Short Antimicrobial Peptides