Autocamtide-3 [KKALHRQETVDAL]

Autocamtide-3 [KKALHRQETVDAL] is a synthetic research peptide in the CaMKII/autocamtide family. The listed sequence/design is Lys-Lys-Ala-Leu-His-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu. Autocamtide-2-related inhibitory peptide (AIP; KKALRRQEAVDAL) is used to interrogate Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity and signaling.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II by AIP (J Biol Chem 2003).
2. CaMKII inhibition using autocamtide-2-related inhibitory peptide KKALRRQEAVDAL (J Biol Chem 2002).