(Arg)9, FAM-Labeled

FAM-(Arg)9 is a fluorescent polyarginine cell-penetrating peptide. Oligoarginines can cross cellular membranes and have been extensively studied as carriers for intracellular delivery. The FAM label permits visualization and quantitative fluorescence measurements near 494/521 nm.

• cell-penetrating peptide research
• intracellular delivery studies
• cellular uptake imaging
• CPP mechanism studies

Cell association does not necessarily equal cytosolic delivery because polyarginine peptides can remain membrane-bound or endosomally trapped. Include extracellular-fluorescence quenching or complementary localization controls when appropriate.

1. Cell-penetrating peptides: 20 years later, where do we stand?