Some cell-permeable peptides are able to carry cargos across cell membrane even without any covalent links.  Biotinylated peptides, including L- and D-TAT peptides made by LifeTein were used in this study to show that two types of cell surface receptors, heparan sulfate proteoglycans and Neuropilin-1, play critical roles in the delivery of silver-based nanoparticles into cells by cell-permeable peptides.

Nano Particles & Cell-Permeable Peptides

Science Advances 06 Nov 2015: Vol. 1, no. 10, e1500821 DOI: 10.1126/sciadv.1500821.  Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic CPP peptides.

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