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Proteasome Substrate II, Z-Leu-Leu-Glu-7-amido-4-methylcoumarin, Z-LLE-AMC |
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Z-Leu-Leu-Glu-AMC, Z-Leu-Leu-Glu-7-amido-4-Methylcoumarin |
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5 mg |
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>95% |
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LTC-003 |
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348086-66-8 |
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664.8 |
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C35H44N4O9 |
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Proteasome Substrate II, Z-LLE-AMC, is a fluorogenic substrate for the peptidylglutamyl-peptide hydrolyzing (caspase-like) activity of the proteasome. Z-LLE-AMC's Caspase-like activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin). AMC is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC can be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazoleis. |
